Combining task-related activation and connectivity analysis of fMRI data reveals complex modulation of brain networks

25Citations
Citations of this article
78Readers
Mendeley users who have this article in their library.

Abstract

Task-related effects in functional magnetic resonance imaging (fMRI) data are usually analyzed with local activation approaches or integrative connectivity approaches, for example, by psychophysiological interaction (PPI) analysis. While both approaches are often applied to the same data set, a systematic combination of the results with a whole-brain (WB) perspective is rarely conducted and the relationship between task-dependent activation and connectivity effects is relatively unexplored. Here, we combined brain activation and graph theoretical analysis of WB-PPI results in an exemplary episodic memory data set of N = 136 healthy human participants and found regions with congruent as well as incongruent activation and connectivity changes between task and control conditions. A comparison with large-scale resting state networks showed that in congruent as well as incongruent regions task-positively modulated connections were mainly between-network connections, especially with the default mode network, while task-negatively modulated connections were mainly found within resting state networks. Over all regions, the strength of absolute activation effects was associated with the tendency to exhibit task-positive connectivity changes, mainly driven by a strong relationship in negatively activated regions. These results demonstrate that task demands lead to a complex modulation of brain networks and provide evidence that task-evoked activation and connectivity effects reflect separable and complementary information on the macroscale brain level assessed by fMRI. Hum Brain Mapp 38:5726–5739, 2017. © 2017 Wiley Periodicals, Inc.

References Powered by Scopus

The human brain is intrinsically organized into dynamic, anticorrelated functional networks

6901Citations
N/AReaders
Get full text

Maps of random walks on complex networks reveal community structure

3449Citations
N/AReaders
Get full text

Psychophysiological and modulatory interactions in neuroimaging

2572Citations
N/AReaders
Get full text

Cited by Powered by Scopus

A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults

50Citations
N/AReaders
Get full text

A SENtence Supramodal Areas AtlaS (SENSAAS) based on multiple task-induced activation mapping and graph analysis of intrinsic connectivity in 144 healthy right-handers

47Citations
N/AReaders
Get full text

The chronnectome of musical beat

33Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Gerchen, M. F., & Kirsch, P. (2017). Combining task-related activation and connectivity analysis of fMRI data reveals complex modulation of brain networks. Human Brain Mapping, 38(11), 5726–5739. https://doi.org/10.1002/hbm.23762

Readers over time

‘17‘18‘19‘20‘21‘22‘23‘24‘2505101520

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 34

72%

Researcher 9

19%

Professor / Associate Prof. 4

9%

Readers' Discipline

Tooltip

Neuroscience 16

38%

Psychology 15

36%

Engineering 6

14%

Agricultural and Biological Sciences 5

12%

Save time finding and organizing research with Mendeley

Sign up for free
0