Functional brain abnormalities in chronic pain: A review

Abstract

The review was performed to investigate the functional brain alterations in patients with various kinds of chronic pain including fibromyalgia, chronic low back pain, migraine and the other chronic pain conditions. In these patients functional connectivity was different not only in the sensory-motor system but also in the affective and reward system. New technology have allowed us to identify and understand the neural mechanisms contributing to chronic pain, which provides us novel targets for future research and treatment.