Deletion polymorphism of Disc1 is common to all 129 mouse substrains: Implications for gene-targeting studies of brain function

Abstract

We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells. Copyright © 2006 by the Genetics Society of America.