K2S2O8-Mediated Efficient Oxidative Deoximation of Flavonoid Oximes under Mild Reaction Conditions

Abstract

Developed a novel K2S2O8-mediated methodology for the oxidative deoximation of flavanone and chalcone oximes to synthesize the corresponding flavanones and chalconesin good to excellent yields (92-70%). Our methodology is successfully applied for the deoximation of flavanone oximes, chalcone oximes, ketoximes and aldoximes. This methodology is equally useful for the hindered and functionalized aldoximes and ketoximes. Mild reaction condition, shorter reaction time, high yields, easy work-up and purification of the products are the key advantages of the methodology.