Effect of node status on breast cancer survival by subtype: A single-center retrospective cohort study

Abstract

Background: Nodal involvement and molecular subtypes were used as independent prognostic indicators in women with breast cancer. However, they did not adequately address the effect of node status by subtype in outcomes. Methods: We performed a retrospective review of data from 2004 to 2011 from the Affiliated Union Hospital of Fujian Medical University with newly diagnosed stage I to III breast cancer to investigate the relationship between node status and 5-year disease-free survival (DFS) and breast cancer-specific survival (BCSS) by molecular subtype. The Cox proportional hazards model was used for multivariate analysis. Results: Median follow-up time was 6.4 years. Luminal HER2 and luminal B were the subtypes with a higher percentage of nodal involvement and high-volume nodal involvement (≥4 positive lymph node) than luminal A. The effect of node status on the prognosis varied with molecular subtype. There was no difference in 5-year DFS and BCSS between stage N1 or N2 and N0 groups in patients with luminal A disease. Nodal involvement in women with the luminal B, luminal HER2, and triple-negative subtypes showed significant difference for 5-year DFS and BCSS compared to the node negative group. Conclusions: Nodal involvement seems to be associated with worse survival in women with the luminal B, luminal HER2, and triple-negative subtypes, but not with the luminal A subtype.