ANTICANCER EFFECTS OF TOW TRADITIONAL DRINKS HIBISCUS (Hibiscus sabdariffa LINN) AND LIQUORICE (Glycyrrhiza glabra)

Abstract

Breast cancer (MCF-7), as well as liver cancer (HepG2), were the leader among new cancer cases. The objective of this study is to assess the viability percentage of tow traditional drinks (hibiscus and liquorice extracts) toward human breast and liver cancer cell lines at different concentrates from 250 to 5000 µg/ml in hibiscus extract and from 50 to 3000 µg/ml in liquorice extract. The viability percentage of hibiscus on breast and liver cancer cell lines were 86.9% and 84.7% at 5000 µg/ml, respectively. The IC 50 of the hibiscus extract were 18478.6 µg/ml and 16159 µg/ml breast and liver cancer. In addition, the viability percentage of liquorice extract on breast and liver cancer cell lines were determined. Results revealed that liquorice extract has possessed high anti-carcinogenic properties it was zero (%) at 3000 µg/ml for breast cancer and 5% for liver cancer at same concentration, the IC 50 was 491.7 µg/ml in breast cancer and was 125 µg/ml in liver cancer cell line. DNA damage was determined to detect oxidative DNA damage in HepG2 cell line. This enhances the role of these traditional drinks especially liquorice as anti-cancer agents.