Nanoscale self-assemblies of PEG-poly(amino acid) block copolymers: Polymeric micellar DDS

Abstract

We have extensively developed polymeric micelles by engineering functional block copolymers that are mainly composed of poly(ethylene glycol) (PEG) and poly(amino acid) segments, directed toward smart drug and nucleic acid delivery. Polymeric micelles have a basic structure of drug-loaded hydrophobic core and biocompatible PEG shell, associated with a size of less than 100 nm and narrow size distribution. These properties allow the polymeric micelles for stable circulation in the bloodstream and preferential tumor accumulation through the enhanced permeability and retention (EPR) effect. Moreover, fine-tuning of chemical structures of block copolymers can further functionalize the polymeric micelles for enhanced stability, programmed drug release, and active targeting. This article aims to facilitate understanding of basic characteristics of polymeric micelles and their recent progress, mainly by reviewing our studies.