Aminolysis of N-tritylamino acid benzotriazolyl esters with concentrated aqueous amines and its applications in synthesis

Abstract

Aminolysis of (S)-N-tritylamino acid benzotriazolyl esters with concentrated aqueous amines produces high yields of the corresponding amides which can be readily detritylated with p-toluensulfonic acid or reduced with lithium aluminium hydride to provide chiral ethane- 1,2-diamine derivatives. © Acta Chemica Scandinavica 1998.