Direct Regioselective Alkylation of Non-Basic Heterocycles with Alcohols and Cyclic Ethers through a Dehydrogenative Cross-Coupling Reaction under Metal-Free Conditions

Abstract

A metal-free, simple, and highly efficient method for the direct alkylation of non-basic heterocycles and basic ones with various alcohols and cyclic ethers has been developed based on an oxidative C–H activation process. The corresponding products were generated through a dehydrogenative C–C cross-coupling reaction in the presence of di-tert-butyl peroxide in good to high yields.