Post-radiation second malignant tumors after combined treatment of diseases of the upper respiratory tract. Literature review and description of clinical observations

Abstract

The problem of the development of the second tumors after radiation therapy of malignant neoplasms has recently become quite relevant. However, there are no serious studies on this topic. A study of modern databases PubMed, Google Scholar, Scopus, RSCI showed that in 1908 first report on radiation-induced skin cancer was published. In 1948, criteria were formulated that allows us to speak about the radiation-induced nature of the second tumors that developed in the area of the radiation portals used for the irradiation of primary tumors. At the same time, the second tumors, as a rule, have the structure of sarcomas with a frequency of occurrence from 0.03 to 0.8%. The aim of the work is to systematize and generalize the literature data and present our own clinical observations as well. An analysis of the data at our disposal allows us to conclude that the timing of the onset of radiation-induced tumors ranges from 2 to 34 years. In this regard, the terms of observation of all patients who received both independent and pre- and postoperative radiation treatment should be constant throughout the life of the treated patients.