A new bioactive ursane-type triterpenoid from Croton bonplandianum Bail

Abstract

A new triterpenoid 3α-hydroxy-urs-12,15-dien (1) of ursane skeleton along with three others, viz. oleanolic acid (2) and ursolic acid (3) and β-sitosterol (4) were isolated from the root of Croton bonplandianum Bail. Their chemical structures were established on the basis of spectroscopic analysis (IR, 1D NMR, 2D NMR, Mass, etc.) and by chemical means. A probable biosynthetic pathway of compound 1 was also proposed. Preliminary investigation with the new compound showed potent activity against a series of fungal pathogens. [Figure not available: see fulltext.] © 2013 Indian Academy of Sciences.