Synthesis, Characterization and Antibacterial Evaluation of Some Coumarin Derivatives

Abstract

Coumarin derivatives have shown different biological activities. New coumarin derivatives (hydrazones and an amide) were synthesized through multisteps reactions. All the synthesized target compounds were characterized by FT-IR spectroscopy and 1H-NMR analysis. The compounds then evaluated for their anti-bacterial activity by means of Disc-well diffusion against two gram-positive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and two gram-negative bacteria (E. coli and Pseudomonas aeruginosa). The highest activity was demonstrated by compound k2 which found to be highly active against pseudomonas aeruginosa (containing NO2 group which is a strong electron withdrawing group that creates a localized electron deficient sites within molecules).