Endotoxin assay with endotoxin scattering photometry is one of the diagnostic markers of sepsis

Abstract

Endotoxin scattering photometry (ESP) is one of a newly developed clinically applicable method for endotoxin assay. Although ESP is an analogous assay of turbidimetric method, it enables one to detect very small amounts of endotoxin within 1 hour. This is because ESP can directly detect clotting enzyme product, coagulin, which is the first appearance of Limulus amebocyte lysate (LAL) cascade and the precursor of gel clots.