Molecular mechanism of polarized transport

Abstract

Mechanisms of generation and maintenance of cell polarity have been investigated using various organisms and cell lines. During and after the establishment of cell polarity, polarized (vesicular) transport as well as cell-cell adhesion is essential. Here, I introduce each molecular step of polarized transport and the molecules involved there. Usually, epithelial cells and neurons are two well-known examples of polarized cells. Thus, I next describe the similarity and difference in polarized transport between these two cell types. Though closely connected, the relationship between cell-cell adhesion and polarized transport remain poorly understood. I will take a few examples indicating the relationship between them. Finally, I will present the future directions in this field. © The Authors 2009. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.