Crystal structure of ethyl 2-(2,4,5-trimethoxyphenyl)quinoline-4-carboxylate

Abstract

In the title compound, C21H21NO5, the dihedral angle between the quinoline ring system (r.m.s. deviation = 0.028 Å) and the trimethoxybenzene ring is 43.38 (5)°. The C atoms of the methoxy groups deviate from their attached benzene ring by -0.396 (2), -0.049 (2) and 0.192 (2) Å for the ortho-, meta and para-substituents, respectively. The pendant ethyl chain is disordered over two orientations in a 0.527 (5):0.473 (5) ratio. A short intramolecular C-H⋯O contact closes an S(6) ring. In the crystal, inversion dimers linked by pairs of weak C-H⋯O interactions generate R22(6) loops. The dimers are linked by further C-H⋯O interactions to generate [11-0] chains.