0498 ASSOCIATION BETWEEN NOCTURNAL INTERMITTENT HYPOXIA AND ACTIGRAPHIC SLEEP QUALITY BETWEEN NOCTURNAL INTERMITTENT HYPOXIA AND ACTIGRAPHIC SLEEP QUALITY

Abstract

Introduction: Intermittent hypoxia at night is an important element of sleep disordered breathing. The purpose of the present study is to clarify the association between nocturnal intermittent hypoxia and objectively measured sleep quality using actigraph. Method(s): For the present study, we recruited 313 participants aged 40 years and over. We conducted an overnight pulse oximetry at home, and assessed nocturnal intermittent hypoxia using 3% oxygen desaturation index (3%ODI). Physical activity was objectively measured using actigraph worn on the non-dominant arm for 7 nights. Based on the self-reported bed time and the rising time, total sleep time (TST), sleep efficiency (SE), and wake after sleep onset (WASO) were calculated for each day, and the mean value was used for analysis. Result(s): The mean age of 313 participants was 66.3 (SD: 9.5) years and 128 (41%) were male. Compared with the lowest tertile group of 3%ODI (T1: <5.9, n=103), the highest tertile group (T3: 3%ODI >=10, n=105) showed similar TST (389 min vs. 388.9 min P= 0.99), significantly lower SE (87.2% vs. 82.1%, P<0.01), and significantly higher WASO (51.2 min vs. 79.5 min, P<0.01). After adjusting for age, gender and body mass index, T3 showed lower SE by 4.48% (95% Confidence Interval: 1.94 to 7.02), and longer WASO by 22.6 min (95%CI: 9.5 to 35.7) than T1. Conclusion(s): We found significant association between nocturnal intermittent hypoxia and actigraphic sleep quality independent of obesity.