Mean platelet volume and other hematological parameters in pediatric migraine

Abstract

Introduction: According to our hypothesis, the mean platelet volume (MPV) value in migraine patients should be lower than in healthy individuals due to recurrent neuroinflammation during headache attacks. Therefore, this study aimed to identify differences between MPV and other hemogram parameters between pediatric patients with migraine and a healthy control group. Material and methods: This study included a total of 80 people, 40 patients and 40 control subjects. Those with hematological diseases, using alcohol or smoking, with malignancy, pregnancy, or with any chronic disease were excluded from the study. Results: Individuals in the control group were chosen to have the same age and same sex as the patient group (p = 0.98). The patient group had statistically significantly higher platelet counts than the control group (p = 0.043). MPV was lower in the patient group compared to the control group (p = 0.001), but platelet distribution width was higher in the patient group compared to the control group (p = 0.034) Conclusions: Migraine patients in the pediatric period were shown in our study to have low MPV values and elevated platelet counts due to recurrent neuroinflammation. This result shows that inflammation especially plays a vital role in migraine pathophysiology.