Mild and efficient one-pot three-component synthesis of benzopyrimidoquinoline-tetraone derivatives in ionic liquids

Abstract

An efficient one-pot synthesis of 5-aryl-5,12-dihydrobenzo[g]pyrimido[4,5- b]quinoline-2,4,6,11(1H,3H)-tetraone derivatives via three-component reaction of aromatic aldehydes, 2-hydroxy-1,4-naphthoquinone and 6-aminouracil in ionic liquid [bmim]BF4 is reported. This method had the advantages of easier work-up, environmentally benign procedure, high yields and ease of recovery and reuse of reaction media.