Chemical constituents of Melicope ptelefolia

Abstract

Phytochemical investigations on the methanolic extract of Melicope ptelefolia Champ ex Benth. resulted in the isolation of three new compounds, identified as 3β-stigmast-5-en-3-ol butyl tridecanedioate (melicoester) (1), (2Z,6Z,10Z,14Z,18Z,22Z,26E)-3′,7′,11′,15′, 19′,23′,27′,31′-octamethyldotriaconta-2,6,10,14,18,22, 26,30-octadecanoate (melicopeprenoate) (2) and p-O-geranyl-7″-acetoxy coumaric acid (3). The compounds were isolated along with twenty-one other known compounds, lupeol (4), oleanolic acid (5), kokusaginine (6) genistein (7), p-O-geranyl coumaric acid (8), 4-stigmasten-3-one (9), 3β-hydroxystigma-5- en-7-one (10) cis-phytyl palmitate (11), dodecane, dodecan-1-ol, ceryl alcohol, hentriacontanoic acid, eicosane, n-amyl alcohol, caprylic alcohol, octatriacontane, nonatriacontane, hexatriencontan-1-ol, methyl octacosanoate, β-sitosterol, β-sitosterol glucoside. Structures of all the compounds were established on the basis of MS and 1D and 2D NMR spectral data, as well as comparison with reported data.