Postoperative pain assessment with concurrent administration of intraperitoneal tramadol and incisional lidocaine following ovariohysterectomy in dogs

Abstract

This study aimed to assess postoperative pain with concurrent administration of intraperitoneal tramadol and incisional lidocaine following ovariohysterectomy in dogs. A group of twenty mixed breed female dogs, aged 1-2 years, weighing 19.5 ± 0.8 kg were used. Initially, dogs were sedated with intramuscular administration of acepromazine 1%. Anaesthesia was induced with diazepam (0.5 mg/kg) and ketamine (10 mg/kg) and maintained with 1.5% Isoflurane. Ketoprofen (2 mg/kg) was administered intravenously just before the initiation of the surgery. Five minutes before midline incision, saline (0.2 ml/kg) was injected to the muscles and subcutaneous space around the incision in the tramadol-saline (TS) group. Also, in the tramadol-lidocaine (TL) group, lidocaine 2% with epinephrine (1.5 mg/Kg) was administered subcutaneously. Ovariohysterectomy was performed and before closing the linea alba, tramadol (4 mg/kg) was splashed on the abdominal viscera in both groups. Cortisol, vital signs and pain scoring systems were evaluated at different time points. Heart rate, respiratory rate and rectal temperature changes were not statistically significant between groups. Cortisol level showed a significant difference between groups at 1, 3 and 6 hours after surgery (p≤0.05). Both UMPS and CMPS-SF pain scores in the TL group were significantly lower than the TS group at 30 minutes, 1, 3 and 6 hours after surgery (p≤0.05) and also at 12 hours after surgery (p≤0.05). It seems that intraperitoneal administration of tramadol (4 mg/kg) along with administration of incisional lidocaine with epinephrine (1.5 mg/kg) is recommended following ovariohysterectomy in dogs.