Complexes of some 3d-metals with a Schiff base derived from 5-acetamido-l,3,4-thiadiazole-2-sulphonamide and their biological activity

Abstract

Using a bidentate ligand, a Schiff base of 5-acetamido-l,3,4-thiadiazole-2- sulphonamide, complexes of transition metals having the general formula ML 2, where M = Mn(II), Fe(II), Ni(II) and Cu(II), were synthesized. The complexes were characterized by elemental analysis, molar conductivity, magnetic moment, electronic, ESR and IR spectroscopy, and particle size analysis. The conductivity data of the complexes suggests their non-electrolytic nature. The stability constants and free energy change for the complexes were calculated. Spectral studies and magnetic susceptibility measurements revealed an octahedral geometry for all the complexes. The ligand and its complexes were screened for their fungicidal activity against Aspergillus niger and A. flavus. 2011 Copyright (CC) SCS.