The mitochondrial free radical theory of ageing -Where do we stand?

Abstract

Understanding the molecular mechanisms underlying the ageing process may provide the best strategy for addressing the challenges posed by ageing populations worldwide. One theory proposing such molecular mechanisms was formulated 50 years ago. Harman et al. suggested that ageing might be mediated by macromolecular damage through reactions involving reactive oxygen species (ROS). Today, a version of the freeradical theory of ageing, focusing on mitochondria as source as well as target of ROS, is one of the most popular.