Naucleamides A-E, new monoterpene indole alkaloids from Nauclea latifolia

Abstract

Five new monoterpene indole alkaloids, naucleamides A-E (1-5), were isolated from the bark and wood of Nauclea latifolia, and the structures and relative stereochemistry were elucidated from the spectroscopic data. Naucleamide E (5) is a unique monoterpene indole alkaloid possessing a pentacyclic ring system with an amino acetal bridge. © 2003 Pharmaceutical Society of Japan.