Structural revision and total synthesis of azaspiracid-1, part 2: Definition of the ABCD domain and total synthesis

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Abstract

The chase for the structure of azaspiracid-1 has ended with a revised structure (see picture). The total synthesis of this challenging target has closed another chapter in this intriguing chemical detective story and allowed the assignment of the relative and absolute configuration of the molecule.

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Nicolaou, K. C., Koftis, T. V., Vyskocil, S., Petrovic, G., Ling, T., Yamada, Y. M. A., … Frederick, M. O. (2004). Structural revision and total synthesis of azaspiracid-1, part 2: Definition of the ABCD domain and total synthesis. Angewandte Chemie - International Edition, 43(33), 4318–4324. https://doi.org/10.1002/anie.200460696

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