Nagelamide I and 2,2'-Didebromonagelamide B, new dimeric bromopyrrole-imidazole alkaloids from a marine sponge agelas sp

Abstract

New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric bromopyrrole- imidazole alkaloid consisting of two subunits connected with a single bond. © 2014 The Pharmaceutical Society of Japan.