Model-based reverse translation between veterinary and human medicine: The one health initiative

Abstract

There is growing concern about the limitations of rodent models with regard to recapitulation of human disease pathogenesis. Computational modeling of data from humans and animals sharing similar diseases provides an opportunity for parallel drug development in human and veterinary medicine. This ‘‘reverse translational’’ approach needs to be supported by continuing efforts to refine the in silico tools that allow extrapolation of results between species.