ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION USING INTRA-ORAL IVABRADINE: A CLINICAL STUDY

Abstract

Background: The role of anaesthesia and its level of safety in patients have gained prime importance. Therefore, the present study evaluates the effect of oral ivabradine on the hemodynamics during laryngoscopy and endotracheal intubation in patients undergoing surgical procedures under general anaesthesia. Materials and Methods: This prospective randomised, single-blinded controlled study was conducted at Government Kilpack Medical College Hospital and Government Roya pettah Hospital, Chennai, between May 2021 and October 2021. Forty-six adult patients undergoing surgeries under general anaesthesia belonging to ASA PS 1 were selected. Total patients were divided into two groups as test (n=23, who received oral Ivabradine 5mg on a tablet at 6 pm on the evening before the day of surgery and one 5mg tablet one hour before intubation) and control group (n=23, tablet B complex one-hour intubation). Result: The mean age in years was 39.24± 9.290 (years) in group 1 and 60.82 ±8.535 (years) in group 2. The mean weight in kilograms was 53.78±4.705 (Kg) in group 1 and 53.60 ± 3.580 (Kg) in group 2. There was no statistically significant difference between the two groups. The change in heart rate in group I and group II was statistically significant. Mean systolic blood pressure was raised during induction and returned to preoperative level within 3 minutes after intubation. Mean systolic pressures were within normal limits. There was no statistically significant difference between the two groups. Conclusion: Ivabradine is an extremely useful drug to prevent an abnormal increase in HR seen during laryngoscopy and endotracheal intubation. Its proven safety enhances its claim for routine use in all patients at risk for hypertension during laryngoscopy and endotracheal intubation.