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Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans

Microbiology and Immunology (2004) 48(10) 783-785
DOI: 10.1111/j.1348-0421.2004.tb03595.x
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Abstract

Candida albicans ura3 mutants were found to produce large amounts of orotic acid when the growth medium was supplemented with sodium acetate. Experiments with 13C-labeled acetate showed that the acetate served as a precursor of orotic acid. This system of acetate-mediated production of orotic acid is similar to other documented microbial producers in yield but unique for its acetate requirement.

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Nezu, T., & Shimokawa, O. (2004). Acetate-mediated production of orotic acid by ura3 mutants of Candida albicans. Microbiology and Immunology, 48(10), 783–785. https://doi.org/10.1111/j.1348-0421.2004.tb03595.x

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