Abstract
Synthesis of chimeric 9-mer oligonucleotides containing methylphosphonate-linkages and locked nucleic acid (LNA) monomers, their binding affinity towards complementary DNA and RNA, and their 3′-exonucleolytic stability are described. The obtained methylphosphonate-DNA/LNA chimeric oligonucleotides display similarly high RNA affinity and RNA selectivity as a corresponding 9-mer DNA/LNA chimeric oligonucleotide, but much higher resistance towards 3′-exonucleolytic degradation. © 2009 Elsevier Ltd. All rights reserved.
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Nagahama, K., Veedu, R. N., & Wengel, J. (2009). Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides. Bioorganic and Medicinal Chemistry Letters, 19(10), 2707–2709. https://doi.org/10.1016/j.bmcl.2009.03.116
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