MTOR and epileptogenesis in developmental brain malformations

Abstract

Tuberous sclerosis complex and related malformations of cortical development represent common developmental causes of intractable epilepsy. Abnormalities in the mammalian target of rapamycin pathway may be central to the pathophysiology of epilepsy and other neurologic deficits in these disorders and serve as a rational target for antiepileptogenic or disease-modifying therapies. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.