Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives

Abstract

A series of N-acetyl pyrazole derivatives, 1-acetyl-3-aryl-5-[5'-(4-nitrophenyl)-2'-furyl]-4,5-dihydro-1H-pyrazoles (5a-j) were synthesized by cyclocondensation reaction between 1-aryl-3-[5-(4-nitrophenyl)-2-furyl]prop-2-en-1-ones (4a-j) and hydrazine hydrate in glacial acetic acid at reflux temperature. Before that, compounds (4a-j) were synthesized by the condensation of 5-(4-nitrophenyl) furan-2-carbaldehyde (3) with various aromatic ketones by using alkali as catalyst. The constitution of the synthesized products has been characterized by using elemental analysis, Infrared,1H-NMR, 13 C-NMR spectroscopy and further supported by Mass spectroscopy. All the products have been screened for their in-vitro biological assay like antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40 µg/ml. It was exposed that the compounds 5a, 5b, 5c, 5d, 5g, 5h and 5j showed motivating antibacterial and antifungal activity compared to the used reference standard.