MAC-sparing effect of transdermal fentanyl in sevoflurane-anesthetized sheep

Abstract

Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic µ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in non-pregnant ewes. Nine sheep were mask induced with sevoflurane (SEVO in oxygen). MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 µg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (P < 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.