Application of Structured Light Illumination and Compressed Sensing to High Speed Laminar Optical Fluorescence Tomography

Abstract

We constructed experiment system to verify the principle of CLOT using optical phantoms containing fluorophore. We used a digital mirror device (DMD) with high speed pattern switching capability (with interval of 1 ms). Fluorescent dye contained in a capillary with internal diameter of 1.4 mm was immersed in light scattering and absorbing medium contained intralipid. Location of the fluorophore was estimated by the proposed method. The reconstruction accuracy at the deep position (depth: 1.9 mm) was less than 0.4 mm. while the error was as large as 1 mm for the shallow position (depth: 0.6 mm) It is considered that accurate measurement of the optical constant is required for better reconstruction accuracy.