Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes

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Abstract

The amphiphilic polyene amphotericin B, a powerful treatment for systemic fungal infections, is shown to exhibit a critical aggregation concentration, and to form giant helically-twisted nanostructures via self-assembly in basic aqueous solution.

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Hamley, I. W., Kirkham, S., Kowalczyk, R. M., Castelletto, V., Reza, M., & Ruokolainen, J. (2015). Self-assembly of the anti-fungal polyene amphotericin B into giant helically-twisted nanotapes. Chemical Communications, 51(100), 17680–17683. https://doi.org/10.1039/c5cc08224b

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