Dynamic simulation of insulin-glucose interaction in type 1 diabetes with MATLAB Simulink®

Abstract

Diabetes is a complex multifactorial disease where a person endures hyperglycemia in a long period. There have been large interest to perform dynamic simulation of insulin-glucose interaction to obtain a new insight of glucose homeostasis in a diabetic patient. Type 1 diabetes is characterized by the inability of β-cell in the pancreas to produce insulin and hence type 1 diabetes patient needs continuous insulin injection throughout their lives. Here, an educational module for process control in chemical engineering education has been developed to describe the insulin-glucose interaction. The model used an extended version of the minimal model (Bergman model) to simulate the interaction of insulin-glucose using state-space and SIMULINK. The state-space model development through classic linearization method followed by open-loop as well as a closed-loop simulation in SIMULINK was presented. The model was then used to simulate the meal disturbance over 24 h of simulation time. Various PI parameters were compared based on ITAE tuning methods in order to evaluate the dynamics of insulin-glucose interaction.