Stability of Bronchodilaters Using New Ultrasonic Nebulizer

Abstract

Ultrasonic nebulization is widely performed for inhalant therapy. But there still remain some problems in the stability of the drugs in inhalant solutions during ultrasonic nebulization. We have reported that the remaining ratios of some bronchodilaters were below 90% after nebulization using the conventional ultrasonic nebulizer. A new ultrasonic nebulizer has been developed by OMRON. We investigated the effect of the new ultrasonic nebulizer on the stability of bron-chodilaters for inhalant therapy. Stability tests were performed on bronchodilaters in terms of visible change, pH and degradation rate of the drug using HPLC after ultrasonic nebulization. The results may be summarized as follows. The ratios of all bronchodilaters remained at more than 95% after 8 minutes of ultrasonic nebulization using the new ultrasonic nebulizer. Therefore, bronchodilaters are highly stable using new ultrasonic nebulizer and should be effective. We concluded that the new ultrasonic nebulizing method can be applied in the inhalant therapy of many inhalant preparations. © 1995, Society of Oto-rhino-laryngology Tokyo. All rights reserved.