Biochemical evaluation of duku’s mistletoe leave (Dendrophthoepentandra (L.) Miq) extract with antidiabetic potential

Abstract

Inhibition of α-glucosidase is a method used to identify bioactive secondary metabolite that has the potency to treat diabetic. The aim of this study was to evaluate the biochemical activity (i.e. antioxidant and inhibition of α-glucosidase) of four different types of Dendrophthoepentandra (L.) Miq leaves extract through the α-glucosidase inhibitory method. The extracts were obtained using maceration and column chromatography methods. The resulted in four extracts of Dendrophthoepentandra (L.) Miqleaves, such as extract of methanol, n-hexane, ethyl acetate, and total flavonoid. The α-glucosidase inhibitory effect of Dendrophthoepentandra (L.) Miq leaves extract was carried out using a spectrophotometer. The greatest inhibition of α-glucosidase was found in total flavonoid with IC50 value of 57,29 ± 0,63 ppm. These total flavonoid leaves extract can be proposed as a potential antidiabetic agent.