Síntese de 1-indanonas através da reação de acilação de Friedel-Crafts intramolecular utilizando NbCl5 como ácido de Lewis

Abstract

Recebido em 17/12/07; aceito em 27/2/08; publicado na web em 2/4/08 SYNTHESIS OF 1-INDANONES THROUGH THE INTRAMOLECULAR FRIEDEL-CRAFTS ACYLATION REACTION USING NbCl 5 AS LEWIS ACID. The intramolecular Friedel-Crafts acylation reaction of 3-arylpropanoic acids to give 1-indanones can be effected in good yields under mild conditions (room temperature) by using niobium pentachloride. Our results indicate that NbCl 5 acts both as reagent (to transform carboxylic acids into acyl chlorides) and as catalyst in the Friedel-Crafts cyclization.