FEATURES OF MODIFYING EFFECT OF LOW-INTENSITY ELECTROMAGNETIC RADIATION OF NATURAL AND TECHNOGENIC ORIGIN ON VIABILITY AND FUNCTIONAL STATUS OF NEUTROPHILIC GRANULOCYTES

Abstract

Aim. Study effects of microwave electromagnetic radiation (EMR) of the SHF range in vitro on viability and functional status of neutrophilic granulocytes. Materials and methods. Neutrophils of peripheral blood of 30 conditionally healthy donors aged 18 - 20 years were exposed to the effect of broadband (natural, similar to sun radio emission) and mono-frequency (technogenic, similar to emission of cell phones, PCs, microwave ovens, etc.) EMR with frequency range of 4 - 4.34 GHz, generated by a SHF-generator «А1МТ-1». 16 minutes after the effect, viability of neutrophilic granulocytes, phagocytic activity, lysosome activity of cells were studied, N ВТ-reducing ability and cytokine content in supernatant were evaluated. Results. The amount of viable neutrophils significantly reduced after the effect of modelled EMR with technogenic frequency-temporal structure, functional status of viable cells did not change. Neutrophils retained viability after the effect of EMR of natural origin, increased levels of 1 Lip and TNFa was determined in supernatants, functional status of neutrophils of men remained stable, and in women an increase of phagocytic ability and a reduction of production of oxygen radicals was noted. Conclusion. The detected reduction of the amount of viable neutrophils under the effect of EMR of technogenic origin could result in disturbances in the system of innate immunity, other homeostasis elements of the human organism and development of pathologic conditions. At the same time, the detected effects of EMR of natural origin open perspectives of use of modelled microwave EMR of SHF range in prophylaxis and clinical medicine.