Hubungan antara riwayat hipersensitivitas dan kadar imunoglobulin e (IgE) total serum dengan sindrom koroner akut di unit pelayanan jantung terpadu RSUP sanglah denpasar

Abstract

Background: Currently, mast cells are implicated in the pathogenesis of coronary heart disease. Mast cells are the only cell tissue that expresses on the surface of the high affinity receptor for IgE (FCεR) and synthesizes vasoactive, spasmogenic, fibrogenic factors and can damage the connective tissue covering the atheroma plaque so that the plaque is prone to rupture. The aim of this study was to determine the relationship between a history of hypersensitivity and total serum IgE levels with acute coronary syndrome. Methods: This study was an analytic cross-sectional study to determine the relationship between history of hypersensitivity and total serum IgE levels with acute coronary syndrome. The study was conducted at the Integrated Cardiac Service Unit Sanglah Hospital Denpasar with consecutive sampling according to the inclusion and exclusion criteria of 68 samples. Results: The results of the history of hypersensitivity analysis with ACS obtained a p value of 0.685; OR 0.778. Analysis of the relationship between total serum IgE levels and ACS resulted in a p value of 0.000; OR 10.385, a history of hypersensitivity with IMA obtained a p value of 0.187; OR 0.281 and total IgE levels with IMA obtained a p value of 0.584; OR 0.273. Conclusion: There is a relationship between total serum Immunoglobulin E (IgE) levels with acute coronary syndrome and MI. There is no relationship between history of hypersensitivity with acute coronary syndrome or MI.   Latar Belakang: Saat ini, sel mast diimplikasikan dalam patogenesis dari penyakit jantung koroner. Sel mast merupakan satu-satunya jaringan sel yang ekpresinya pada permukaan high affinity receptor untuk IgE (FCεR) dan mensintesis faktor vasoaktif, spasmogenik , fibrogenik dan dapat merusak jaringan ikat yang menutupi plak atheroma sehingga plak rentan pecah. Tujuan Penelitian ini untuk mengetahui hubungan antara riwayat hipersensitivitas dan kadar IgE total serum dengan sindrom koroner akut. Metode: Penelitian ini merupakan penelitian dengan rancangan potong lintang analitik untuk mengetahui hubungan antara riwayat hipersensitivitas dan kadar IgE total serum dengan sindrom koroner akut. Penelitian dilakukan di Unit Pelayanan Jantung Terpadu RSUP Sanglah Denpasar dengan consecutive sampling sesuai kriteria inklusi dan eksklusi sebesar 68 sampel. Hasil: Hasil analisis riwayat hipersensitivitas dengan SKA didapatkan nilai p 0,685; OR 0,778. Analisis hubungan antara kadar IgE total serum drngan SKA didapatkan hasil nilai p 0,000; OR 10,385, riwayat hipersensitivitas dengan IMA didapatkan nilai p 0,187;OR 0,281 serta kadar IgE total dengan IMA didapatkan hasil nilai p 0,584; OR 0,273. Simpulan: Terdapat hubungan antara kadar Immunoglobulin E (IgE) total serum dengan sindrom koroner akut dengan IMA. Tidak terdapat hubungan antara riwayat hipersensitivitas dengan sindom koroner akut maupun IMA.