Using transrectal ultrasound to examine the effect of exogenous progesterone on early embryonic loss in sheep

Abstract

The financial impact of early embryonic loss in Australia may be as high as $137 million AUD/year. Embryos may be lost due to environmental conditions, or maternal factors such as nutrition or progesterone (P4) profiles. However, studies on the supplementation of P4 during early pregnancy have returned contradictory results, partly as a reliable method of detecting embryos in the early stages of gestation ( <0.05). The majority of embryonic loss occurred between pre- and peri-implantation (0.9±0.15 per ewe; P<0.001). No further loss was recorded after this point. Ewes that were given P4 at day 0 had significantly higher embryonic loss (77%) compared to the control (52%) and day 3-ewes (56%; P<0.05). These results show TRUS is a viable tool for investigating early embryonic loss and that the variability noted in previous P4 supplementation studies may be due to variation in time and length of treatment.