Comparative analyses of Weibull model and conventional kinetics models of drug release of formulated multi-component tablets

Abstract

The kinetic study of drug release is an essential requirement to examine the ability of the drug formulation to modulate the typical drug release profile. In the present work, the Weibull model and other traditional drug release models are selected to investigate the release of tablets prepared using different drying techniques in a simulated abdominal solution. These tablets are prepared using electromagnetic microwave irradiation tablet (MVT), convective drying tablet (CVT), freeze drying tablet (FRT), vacuum drying tablet (VAT), and without any drying process tablet (NDT). This study aims to compare Weibull models with other conventional drug release models in inspecting the kinetics of drug release in all tablets. These models are Zero-Order, Higuchi, First-Order, Hixson-Crowell, and Korsmeyer-Peppas. This work delves into the best kinetic model that defines the tablets’ release mechanisms, including the new multicomponent tablets (MVT), to ensure their release is in appropriate behavior. The results show that the Weibull model is the best model to present the release profile of all tablets except for MVT and VAT, while Higuchi is the optimal model for. Among the conventional models, Higuchi, Korsmeyer-Peppas, and Hixon-Crowell are the best conventional models to fit all types of tablets. Based on the Weibull model factor, non-Fickian diffusion is the dominant release mechanism for NDT and VAT. Although Fick diffusion controls the drug release mechanism of FTR, CVT, and MVT tablets. Additionally, three modified models were created and found to be more convenient to denote the release of the formulated tablets with very high accuracy.