Serum carbohydrate antigen 153 and renal function in patients with type 2 diabetes mellitus

Abstract

Objective: The aim of our study was to investigate the correlation between serum carbohydrate antigen 153 (CA153) and renal function in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 184 patients with T2DM were included, and renal function was assessed by the modification of diet in renal disease (MDRD) formula adjusted coefficient of the Chinese people. Results: Serum CA153 concentrations were positively correlated with blood glucose (BG) and glycated hemoglobin (HbA1c) (r =.204, P =.005; r =.165, P =.025) in patients with T2DM. There was a negative correlation between serum CA153 and estimated glomerular filtration rate (GFR) (r = −.229, P =.002) in whole patients with T2DM; similarly, the correlations were observed in both women and men (r = −.228, P =.028 for women, r = −.231, P =.028 for men). Multiple linear regression analysis suggested that serum CA153 was still significantly correlated with estimated GFR (beta = −0.286, P