Determining the role of the aromatic ring of N-arylmethyl entconduramine F-1 in their interactions with α-glucosidases by saturation transfer difference NMR spectroscopy experiments

Abstract

Saturation transfer difference (STD) NMR spectroscopy was used to study the role of aromatic moieties in the inhibition of α-glucosidases by N-arylmethyl ent-conduramine F-1. STD epitope mapping and molecular docking simulations provide new insights into the structure-based design of drugs targeting this enzyme (see figure). © 2012 The Authors.