The GABAAγ2(R43Q) mouse model of humangenetic epilepsy

Abstract

γ-Aminobutyric acid (GABA)A receptors mediate phasic and tonic inhibition in the brain, and epilepsy-associated mutations are found in GABAA genes. This chapter discusses a mouse model of human genetic epilepsy and how it has informed our understanding of the role of GABA A receptor dysfunction in patients. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.