Research Progress in the Fluorescent Probes for Alkaline Phosphatase

Abstract

Alkaline phosphatase (ALP) is an important enzyme for various mammalian tissues. As a biomarker and diagnostic indicator, ALP provides important information for the applied research of molecular biology and the treatment of human diseases. Due to its reliability of information in human health, the research on fluorescence detection as important detection method has become intense in recent years. The fluorescent chemosensors are categorized by different luminous feature involving excitedstate intramolecular proton transfer (ESIPT) and intramolecular charge transfer (ICT) chemosensors, aggregation-induced luminescent molecules (AIE), diminishes the electron donating ability (D d-E) and disruption of the π conjugated systems (D π-C), inner filter effect (IFE) chemosensors, and other sensing systems. In the end, the development tendency of the sensing ensembles for ALP is prospected.