Long-Term Histologic Changes in Nasal Mucosa after Total Laryngectomy

Abstract

Objective . To determine the long-term histopathologic changes in nasal mucosa and the relationship between progression of the histopathologic changes and the duration without air current stimulation. Material and Method . Biopsies were taken from the inferior turbinates of 11 laryngeal cancer patients after total laryngectomy. Specimens were stained with hematoksilen-eosin and several histopathologic parameters were examined under light microscopy. Results . All of the patients demonstrated at least one histopathologic abnormality (100%, n=11 ). Goblet destruction and stromal fibrosis were the most common findings (81%, n=9 ), followed by focal epithelial atrophy and subepithelial seromusinous gland destruction (45%, n=5 ), neovascularization and congestion (36%, n=4 ), complete epithelial atrophy and mixoid degeneration (27%, n=3 ). According to the duration between laryngectomy and biopsy, patients were grouped in to three: group 1; less than 12 months (36%, n=4 ), group 2; 12–36 months (18%, n=2 ), and group 3; more than 36 months (45%, n=5 ). Only congestion was found to be decreased as the duration increased ( P