COMPARATIVE STUDY: FORMULA PRAKTIS ESTIMASI LAJU FILTRASI GLOMERULUS(LFG) DENGAN BIOMARKER KREATININ SERUM

Abstract

LatarBelakang: Estimasi LFG tergolong rumit membutuhkan waktu yang relatif lama, sehingga diperlukan suatu metode praktis dan efisien dengan hasil yang akurat pula. Indonesia merupakan negara dengan pasien penyakit ginjal kronik yang cukup tinggi.Data Riskesdas Kementerian Kesehatan 2013-2018 melaporkan pasien gangguan ginjal usia ?15 tahun yang kian meningkat setiap tahunnya. Dibutuhkan beberapa tes laboratorium untuk memberi gambaran yang tepat mengenai kesehatan ginjal diantaranya: LFG. Terdapat beberapa formula yang telah diteliti sebelumnya oleh para ahli diantaranya:  Formula Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI),Theisotope dilution mass spectrometry (ID-MS) Traceable Modification of Diet in Renal Disease (MDRD), dan Modification of Diet in Renal Disease (MDRD) 4 Variable.Tujuan: Mengetahui perbandingan hasil estimasi LFG berdasarkan formula CKD-EPI, ID-MS Traceable MDRD, dan MDRD 4 Variabel. Metode: Data yang digunakan dalam penelitian seperti kreatinin serum dan usia subjek diperoleh dari data sekunder sebanyak 30 orang. Nilai LFG dihitung dengan formula CKD-EPI, ID-MS Traceable MDRD, dan MDRD 4 Variable.Hasil:  Nilairerata±SD (n=30) LFG berdasarkan  formula CKD-EPI yaitu 71,36±8,77 dengan rentan nilai LFG = 50,70-89,34. Sebayak 93,30 % mengalami kerusakaan ringan (60-89) dan 6,70 % rusak sedang (59-30). Nilai rerata±SD (n=30) LFG berdasarkan  formulathe ID-MS Traceable MDRD yaitu 64,79±6,59 dengan rentan nilai LFG = 48,48-78,40. Sebayak 83,30 % mengalami kerusakaan ringan (60-89) dan 16,70 % rusak sedang (59-30). Nilai rerata±SD (n=30) LFG berdasarkan  formula MDRD 4 Variable  yaitu 68,86±7,00 dengan rentan nilai LFG = 51,53-83,33. Sebayak 93,30 % mengalami kerusakaan ringan (60-89) dan 6,70 % rusaksedang (59-30).Kesimpulan: Penggunaanketiga (3) formula tersebut dapat digunakan untuk menghitung LFG. Kendati demikian, formula CKD-EPI atau pun MDRD 4 Variabel lebih direkomendasikan.Background: Estimation GFR is complicated to take a relatively long time, so it takes a practical and efficient method with accurate results as well. Indonesia is a country with moderately high chronic kidney disease patients. Riskesdas Data Ministry of Health 2013-2018 reported patients with kidney failure age ? 15 years of increasing each year. It takes several laboratory tests to give a proper picture of kidney health including: LFG. There are several formulas that have been researched earlier by experts including: Formula Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI), The isotope dilution mass spectrometry (ID-MS) Traceable Modification of Diet in Renal Disease (MDRD) , and Modification of Diet in Renal Disease (MDRD) 4 Variable. Objectives: Know the comparison of LFG estimates based on the formula CKD-EPI, ID-MS Traceable MDRD, and MDRD 4 Variable. Methods: Data used in research studies such as serum creatinine and subject age are obtained from secondary Data as much as 30 people. The GFR values are calculated with the CKD-EPI formula, ID-MS Traceable MDRD, and MDRD 4 Variable. Result: Average value of ± SD (n = 30) LFG based on the CKD-EPI formula is 71,36 ± 8.77 with the vulnerable value of  GFR = 50,70-89,34. 93.30% suffered mild (60-89) and 6.70% Moderate damage (59-30). The average value of ± SD (n = 30) GFR based on the formula of the ID-MS Traceable MDRD is 64,79 ± 6,59 with vulnerable value of GFR = 48,48-78,40. 83.30% suffered mild (60-89) and 16.70% Moderate damage (59-30). Average value of ± SD (n = 30) GFR based on the MDRD 4 Variable formula is 68,86 ± 7,00 with vulnerable value GFR = 51,53-83,33. 93.30% suffered mild (60-89) and 6.70% Moderate damage (59-30). Conclusion: The use of three (3) such formulas can be used to estimate GFR. Nevertheless, the formula CKD-EPI or MDRD 4 variables are recommended.