Preparation and characterization of etodolac as a topical nanosponges hydrogel

Abstract

Nanosponges (NS) of etodolac (ETO) was prepared using the emulsion solvent diffusion method. Etodolac took as a model drug because of its short half-life, low water solubility; NS is non-irritating, non-mutagenic, non-allergenic and non-toxic suitable to bind to poorly- soluble drugs within the matrix and improve their bioavailability .The effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and characterized.The selected formula was lyophilized then incorporated into hydrogel; which also evaluated .The results show that the formulation that contain Drug:Polyvinyl alcohol: ethylcellulose in ratio 1:3:2 is the best with smallest particle size 40.2±0.098nm with polydispersibility0.005 and in vitro release 97.6%±0.11,, ETO NS Carbopol hydrogel produced a significant(p<0.05) improvement of the in vitro release than pure ETO hydrogel.