Effective, nonsensitizing vaccination with culture filtrate proteins against virulent Mycobacterium bovis infections in mice

Abstract

Vaccination of mice with Mycobacterium boris culture filtrate proteins (CFP), prepared in a variety of adjuvants (aluminum hydroxide, Quil-A, and dimethyldioctyldecyl ammonium bromide [DDA]), provided significant protection against an aerosol challenge of virulent M. boris. Additionally, vaccination with CFP in DDA or Quil-A did not sensitize mice to M. boris purified protein derivative.